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Fig. 6 | Molecular Cancer

Fig. 6

From: STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4

Fig. 6

SOX4 is required for MMP2 and EZH2 expression mediated by HOXD-AS1. a mRNA and protein levels of metastasis-related genes in Huh7 cells with HOXD-AS1 knockdown. b mRNA and protein levels of metastasis-related genes in SNU449 cells with HOXD-AS1 overexpression. c The expression level change of EZH2 and MMP2 after knockdown of SOX4 in SNU449 cells with HOXD-AS1 overexpression. d ChIP assay was performed with antibody against SOX4 or control IgG in Huh28 cells with HOXD-AS1 overexpression or negative control. Immunoprecipitated DNA was analyzed by quantitative PCR. Genomic DNA input was 1%. e A proposed model for illustrating the function and mechanism of HOXD-AS1 in HCC metastasis. Data in A-D are the means ± SD. *p < 0.05, **p < 0.01, and ***p < 0.001

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