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Fig. 10 | Molecular Cancer

Fig. 10

From: PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathway

Fig. 10

β-catenin reverses the tumorigenic growth in the lentiviruses shPRC1 transfected A549, and up-regulates the expression of PRC1. a qRT-PCR analysis of β-catenin mRNA level in A549 cells transfected with β-catenin expressing plasmid or empty vector. β-Actin mRNA expression was used as an internal control. Experiment was conducted in triplicate. * P < 0.05. b A colony formation assay of A549 cells stably transfected with control or PRC1 shRNA with or without β-catenin expressing plasmid. The colonies were counted and captured. *P < 0.05. c qRT-PCR analysis of PRC1 mRNA level in A549 cells transfected with β-catenin expressing plasmid or empty vector. d A proposed working model of PRC1 functions lung adenocarcinoma. PRC1 gene is directly suppressed by P53 and could promote the activation of Wnt/β-catenin signaling in a positive feedback regulatory network. Loss of PRC1 induces G2/M phase arrest and apoptosis in vitro, PRC1 expression is associated with high Wnt/β-catenin potency in lung adenocarcinoma patient tissues and promote metastasis and proliferation

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