Fig. 4

Downregulation of PRC1 inhibits the tumor growth of subcutaneous xenograft tumors in vivo. A549 cells were transduced with lentiviruses shPRC1–1 or shControl and then injected into mouse flanks as described in the text. Tumor growth was measured every 3 days after injection, and the tumors were harvested at day 21 and weighed. a The resected tumors from each group (n = 7) were photographed. b Tumor growth curves were summarized, and the error bars indicate the standard deviation (SD). c Tumor weight is represented as means mean ± S.D. when the tumors were harvested. d Representative images (200×) of HE staining of the resected tumor. IHC analysis showed that PRC1-knockdown decreased the proliferation index Ki67, and reduced the expression of cyclin B1 and Cdc2. *P < 0.05, **P < 0.01