PRC1 knockdown significantly attenuates NSCLC cell migration in vitro and metastasis in vivo.
a Transwell assays were performed to determine the migratory abilities of A549, SPC-A1, and H1299 cells transduced with lentiviruses expressing the indicated shRNA. b Analysis of an experimental metastasis animal model was performed by injecting A549 cells transduced with lentiviruses shPRC1–1 or shControl into nude mice via the tail vein. Representative lung images taken from mice at week 6 are shown. c the number of tumor nodules on lung surfaces are shown. d Representative HE staining of lung tissues from the different groups is shown. **P < 0.01, ***P < 0.005