PLX8394, a new generation BRAF inhibitor, selectively inhibits BRAF in colonic adenocarcinoma cells and prevents paradoxical MAPK pathway activation

Table 1 Mutational status of cell lines used

Cell Line	Type	BRAF	KRAS
LM-MEL-64	Melanoma	V600E	wt
LM-MEL-39	Melanoma	wt	wt
LM-COL-1	Colorectal carcinoma	wt	G12D
LS513 [21]	Colorectal carcinoma	wt	G12D
ALA [12]	Colorectal carcinoma	wt	G12D
LIM2405 [22]	Colorectal carcinoma	V600E	wt
COLO 201 [23]	Colorectal carcinoma	V600E	wt
HCT 116	Colorectal carcinoma	wt	G13D

ISSN: 1476-4598