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Fig. 1 | Molecular Cancer

Fig. 1

From: Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis

Fig. 1

High RAB3C expression is an independent indicator of poor prognosis, distant metastasis and advanced stage in colorectal cancer patients. a Screening of exocytic RAB expression levels using immunohistochemistry (IHC) staining in colorectal cancer identified significant RAB3C overexpression in colorectal cancer tissue compared with normal colonic mucosa. b Increased RAB3C expression was also confirmed through comparison of paired normal and colorectal cancer tissue samples. The scores were calculated as the staining intensity score × the percentage of stained cells. Images were taken at a magnification of 200×. Scale bars represent 100 μm. c Negative and weak cytoplasmic RAB3C IHC staining were classified as low RAB3C expression, and moderate to strong staining cytoplasmic RAB3C IHC staining were classified as high RAB3C expression. Images were taken at a magnification of 400×. Scale bars represent 200 μm. d For stage I to IV patients, early stage patients, and late stage patients, Kaplan-Meier plots show that patients with high RAB3C expression displayed poorer overall and disease-free survival than those with low RAB3C expression. e In multivariate analysis, RAB3C remained an independent prognostic factor for overall and disease-free survival. f High RAB3C expression indicated frequent distant metastasis and late pathological stage in the clinicopathological analysis. All cases were staged according to the 7th version of cancer staging manual of the American Joint Committee on Cancer, and the histological cancer type was classified according to World Health Organization classification

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