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Fig. 5 | Molecular Cancer

Fig. 5

From: Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis

Fig. 5

RAB3C overexpression increases exocytosis of colon cancer cells and promotes metastasis through IL-6 secretion (a) Western blot analysis of RAB3C, RAB3B, RAB26, RAB27A and β-actin protein expression with or without RAB3C overexpression in CX-1 and SW480 cells. b Migration ability of CX-1 cells induced by culture medium from RAB3C-overexpressing or control cells. c Western blot analysis of RAB3C, IL-6 and β-actin protein expression after dose-dependent EXO-1 treatment with or without RAB3C overexpression in CX-1 and SW480 cells. d Migration ability after IL-6 antibody treatment was dose-dependent in a RAB3C model. e Western blot analysis of IL-6 and β-actin protein expression and the migration ability of CX-1 cells after IL-6 dose-dependent knockdown and RAB3C-overexpression

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Molecular Cancer

ISSN: 1476-4598