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Fig. 6 | Molecular Cancer

Fig. 6

From: Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis

Fig. 6

RAB3C enhanced STAT3 phosphorylation through IL-6, thereby promoting colon cancer metastasis (a) IL-6 signaling and the downstream pathway in RAB3C-overexpressing cells. Red indicates upregulation, and green indicates inhibition in the RAB3C-based microarray data. b Western blot analysis of phospho-STAT3, STAT3, RAB3C and β-actin protein expression with or without RAB3C-overexpression in CX-1 cells. c Western blot analysis of phospho-STAT3, STAT3, and β-actin protein expression with and without recombinant human IL-6 treatment. d Western blot analysis of phospho-STAT3, STAT3, and β-actin protein expression with or without Ruxolitinib treatment in a CX-1 RAB3C model. e Effect of different doses of Ruxolitinib on the migration ability of CX-1 cells. f Proposed model of the RAB3C/IL-6 axis in colon cancer progression

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Molecular Cancer

ISSN: 1476-4598