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Fig. 1 | Molecular Cancer

Fig. 1

From: Hypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancer

Fig. 1

Hif-2α mediated hypoxia induced EMT in pancreatic cancer. a Morphology changes of PDAC cells after undergoing hypoxia for 48 h. b PDAC cells underwent hypoxia showed expression changes of hypoxia-related (hif-1α, hif-2α), EMT-related (β-catenin, Snail, Slug, E-cadherin, vimentin), and stemness-related (Oct-4, Sox2, Nanog) genes. c Early and late accumulation of hif-α proteins after different duration of hypoxia. d DFO mimicked hypoxia and induced EMT in PANC-1 and SW 1990 cells. e Regulation of hif-2α level changed vimentin expression in PANC-1 cells. f Overexpression of degradation-resistant hif-2α (A530T) increased invasion capacities of the PDAC cells, and inhibition of hif-2α decreased their invasion abilities. *, P < 0.05 as compared to pcDNA3 or DFO + nc-siRNA

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Molecular Cancer

ISSN: 1476-4598