Fig. 1
From: Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies
Overview of the 34 CRC cell lines analyzed and key findings. a The cell lines are grouped according to the gene expression-based CMSs (except Colo320, which has a neuroendocrine origin), and MSI, POLE and CIMP status are indicated. In general, the morphologic appearance of cell lines in CMS1 and CMS4 (for example LoVo and RKO) was mesenchymal, whereas cell lines in CMS2 and CMS3 (for example IS3 and WiDr) appeared more epithelial-like. b The cell lines were analyzed on the DNA, RNA and protein levels as indicated (blue background). Bioinformatic analyses (grey) were performed both on individual data levels and by integration of two or more data levels. Key findings (white) and references to figures and tables with detailed results are given (green). CIMP: CpG island methylator phenotype, CMS: consensus molecular subtypes, CNA: copy number aberrations, MSI/MSS: microsatellite instable/stable, OG: oncogene, TF: transcription factor, TS: tumor suppressor, SNV: single nucleotide variant