Fig. 5
From: Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies
mRNA and protein expression levels are highly concordant among cell lines. a The density distribution (horizontal axis) of cross-cell line Pearson’s correlations (vertical axis) for expression of matched genes (microarray data) and proteins (Reverse Phase Protein Array data) (n = 194) shows an overall strong correlation. The horizontal line indicates the median correlation coefficient for all gene-protein pairs. b Differential expression analyses between colon-like and undifferentiated cell lines showed strong correspondence at the mRNA and protein level (plotted as the log2 fold-changes between the two groups of cell lines for matched protein on the vertical axis versus mRNA on the horizontal axis). The plot includes gene-protein pairs with adjusted p-value <0.1 from differential expression analysis in either mRNA or protein data. Gene-protein pairs with absolute log2 fold-change >0.5 (mRNA) between colon-like and undifferentiated cell lines are indicated by names and the rest by circles. Pearson correlation analysis (r2) indicated that 43% of the variance in the log2 fold-change at the protein level could be explained by mRNA-level log2 fold-change