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Fig. 2 | Molecular Cancer

Fig. 2

From: WW domain-binding protein 2: an adaptor protein closely linked to the development of breast cancer

Fig. 2

Regulatory mechanisms of WBP2 in breast cancer. a Once nER activated by estradiol, WBP2 then binds to YAP for stimulating the transcriptional activation of ERα. b WBP2 participates in the EGF signaling pathway thru binding to the complex of c-Yes and YAP in breast cancer. c ERα-medicated Wnt expression can activate GSKβ/β-catenin to promote the ERα-launched transcriptional programming. d WWOX binds PPxY domain of WBP2 and sequesters it in the cytoplasm, suppressing WBP2-mediated transcriptional functions. e TAZ interacts with WBP2 to improve the cell proliferation, migration, and survival through Hippo pathway in breast cancer, and the binding of them may also trigger the transcription activation of ERα. f Tyrosine phosphorylation of WBP2 possibly can be activated by several tyrosine kinases via the binding of E2 to mER and be drived into nuclei to function as a coactivator of ER

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