Fig. 1

Aberrant gene expression profile in breast cancer. a Hierarchical clustering of differentially expressed genes in breast cancer relative to normal tissue in cohort I (N = 623). b Hierarchical clustering of differentially expressed genes in breast cancer relative to normal tissue in cohort II (N = 465). Red through blue colour indicates high to low expression levels, respectively. c Upregulated (left) and downregulated (right) lncRNAs from cohort I and cohort II identified via Venny online software analysis (http://bioinfogp.cnb.csic.es/tools/venny/). d Upregulated (left) and downregulated coding genes (right) from cohort I and cohort II. e Expression levels of 30 upregulated lncRNAs in cancer relative to normal tissue (left) and hierarchical clustering of these genes (right) in the TCGA. f Expression levels of 25 downregulated lncRNAs in cancer relative to normal tissue (left) and hierarchical clustering of these genes (right) in the TCGA. The red columns indicate the expression levels of lncRNAs in cancer tissues, and the blue columns represent normal tissues