Fig. 1

FOXP3 is highly expressed in NSCLC and correlated with poor prognosis. a The levels of FOXP3 in 106 paired NSCLC tissues and adjacent normal tissues were scored by IRS method (5) and analyzed by paired t-test. Mean ± SD is shown in the figure. For images of the tissue staining, please refer to Additional file 2: Figure S1. b FOXP3 protein levels were higher in tumor than in peritumoral tissues, as determined by western blot. c Kaplan–Meier representation of the overall survival and recurrence-free survival of the two groups of patients with high (n = 41, solid line) or low (n = 65, dotted line) FOXP3 expression in NSCLC tissues. Statistical analysis was performed with the log-rank test. d Kaplan–Meier representation of the overall survival of the two groups of patients with Treg cell counts >25 (n = 42, solid line) or ≤25 (n = 64, dotted line) in NSCLC tissues. Statistical analysis was performed with the log-rank test