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Fig. 4 | Molecular Cancer

Fig. 4

From: FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer

Fig. 4

FOXP3 promotes tumor metastasis in NSCLC. a Effect of FOXP3 on cell migration was evaluated by wound healing assay in A549 cells. FOXP3-expressing A549 cells had a much stronger healing ability than control cells (p < 0.01). b Effect of FOXP3 on cell invasion was evaluated in A549 cells by Matrigel invasion assay. FOXP3-expressing A549 cells showed higher penetration rate through the Matrigel-coated membrane compared with control cells (p < 0.001). c Soft agar growth analysis demonstrated that FOXP3-expressing A549 and H460 cells had a stronger tumorigenicity than control cells (p < 0.01). d FOXP3 promotes tumor metastasis in vivo. The total number of metastatic nodules was quantified in lungs of nude mice 8 weeks after tail vein injection of control and FOXP3-expressing A549 cells. Values for individual mouse were dotted in the plot and values by group were also denoted. Data are mean ± s.d. Please refer to Additional file 2: Figure S4 for representative images for a, b and d

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Molecular Cancer

ISSN: 1476-4598