Fig. 2
From: Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer
Metformin impaired oncogenic Kras-mediated mPanIN formation in KC mouse model. a H&E staining of the pancreas in vehicle or metformin-treated mice. Scale bars: (top row) = 400 μm; (2nd row) = 100 μm. b Scheme showing the experimental design of metformin treatment protocols in mice. c Quantification of the percentage of CK19 positive duct-like structures in mice treated with vehicle or metformin. d Representative images show pancreatic precursor lesions stained by anti-CK19. Scale bars: top row = 400 μm; 2nd row = 100 μm. e Quantification of the percentage of early mPanIN (ADM plus mPanIN1) and late mPanIN (mPanIN2 plus mPanIN3) in mice treated with vehicle or metformin. *P < 0.05; **P < 0.01