Fig. 5
From: Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer
STAT3 signaling and cell proliferation were suppressed via metformin treatment. a Immunohistochemical staining of phospho-STAT3 in the pancreas of mice treated with vehicle, metformin, cerulein, and cerulein plus metformin. Scale bars =100 μm. b Quantification of the numbers of Ki67-positive cells in different groups. **P < 0.01. c Representative images stained by anti-Ki67. Scale bars: top row = 400 μm; 2nd row = 100 μm