Fig. 6From: Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancerMetformin inhibited the growth and invasion of PDAC in a KPC mouse model. a Representative macroscopic images of PDAC in KPC mice treated with vehicle or metformin. The white dotted line shows the pancreas. b Histology of tumors from KPC mice in groups as indicated. c Quantification of tumor weight in mice treated with vehicle or metformin. d Representative images of bile duct invasion (a), peritoneal invasion and ascites (b), mesenteric invasion (c) and diaphragmatic invasion (d) identified in KPC mice. e Table listing the incidence of abdominal invasion in KPC mice treated as indicated. f Representative images of Masson’s trichrome staining. g Quantification of Masson’s trichrome in mice as indicated. h Kaplan-Meier survival analysis of KPC mice treated with vehicle or metformin. **P < 0.01Back to article page