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Fig. 7 | Molecular Cancer

Fig. 7

From: Long non-coding RNA CASC2 suppresses epithelial-mesenchymal transition of hepatocellular carcinoma cells through CASC2/miR-367/FBXW7 axis

Fig. 7

miR-367 mediated the tumor suppressive effects of CASC2 in HCC. a miR-367 restoration reduced the expression of FBXW7 in CASC2-overexpressing MHCC-97H cells. b miR-367 knockdown increased the level of FBXW7 in CASC2-underexpressing Hep-3B cells. c Transwell assays showed that miR-367 could largely reverse the suppressive effects of CASC2 on migration and invasion of MHCC-97H cells. d miR-367 silencing abrogated the pro-metastatic effects of CASC2 knockdown in Hep-3B cells. e miR-367 could largely reverse the suppressive effects of CASC2 on EMT progression of MHCC-97H cells. f miR-367 silencing abolished the promoting effects of CASC2 on EMT progression of Hep-3B cells. *P < 0.05, **P < 0.01

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Molecular Cancer

ISSN: 1476-4598