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Table 1 Correlation between the clinicopathologic characteristics and CASC2 and miR-367 expression in HCC (n = 75)

From: Long non-coding RNA CASC2 suppresses epithelial-mesenchymal transition of hepatocellular carcinoma cells through CASC2/miR-367/FBXW7 axis

Clinical parameters Cases Expression level P value Expression level P value
CASC2high (n = 38) CASC2low (n = 37) miR-367high (n = 38) miR-367low (n = 37)
Age(years)
 < 50 24 13 11 0.677 10 14 0.285
 ≥ 50 51 25 26 28 23
Gender
 Male 64 34 30 0.304 32 32 0.781
 Female 11 4 7 6 5
HBV
 Absent 13 9 4 0.141 7 6 0.801
 Present 62 29 33 31 31
Serum AFP level (ng/mL)
 < 400 18 11 7 0.127 6 12 0.092
 ≥ 400 57 27 30 32 25
Tumor size (cm)
 < 5 34 21 13 0.080 12 22 0.015a
 ≥ 5 41 17 24 26 15
Number of tumor nodules
 1 62 35 28 0.104 30 32 0.389
 ≥ 2 13 4 9 8 5
Cirrhosis
 Absent 20 12 8 0.330 7 13 0.102
 Present 55 26 29 31 24
Venous infiltration
 Absent 54 33 21 0.004a 23 31 0.025a
 Present 21 5 16 15 6
Edmondson-Steiner grading
 I + II 49 29 20 0.043a 22 27 0.170
 III + IV 26 9 17 16 10
TNM tumor stage
 I + II 56 34 22 0.003a 24 32 0.020a
 III + IV 19 4 15 14 5
  1. HCC hepatocellular carcinoma, HBV hepatitis B virus, AFP alpha-fetoprotein, TNM tumor-node-metastasis
  2. aStatistically significant