Fig. 7
From: EGFR modulates monounsaturated fatty acid synthesis through phosphorylation of SCD1 in lung cancer
SCD1 Y55 phosphorylation is related to EGFR activation, SCD1 protein expression and poor patient survival in NSCLC. a Immunohistochemistry (IHC) staining of phospho-EGFR Y1092, phospho-SCD1 Y55 and SCD1 protein expression in the representative non-small cell lung cancer (NSCLC) samples with high (Case 1) or low (Case 2) levels. Scale bars represent 50 μM. b Correlation between phospho-EGFR Y1092 and phospho-SCD1 Y55 or SCD1 protein expression in NSCLC tissues. p values were calculated by chi-square test. c Relationship between SCD1 Y55 phosphorylation and SCD1 protein expression in NSCLC tissues. p values were calculated by chi-square test. d Representative IHC staining of phospho-SCD1 Y55 in NSCLC tissues and the paired adjacent normal tissues. p values were calculated by chi-square test. Scale bars represent 50 μM. e and f Kaplan-Meier analysis of overall NSCLC patient survival based on SCD1 Y55 phosphorylation or SCD1 protein expression in IHC staining. p values were calculated by log-rank test