Fig. 6
Overexpression of miR-218 represses tumor growth in vivo. a A549 cells were infected with lentivirus expressing miR-218 or miR-control. Forty-eight hours after infection, cell proliferation was determined. b 5 × 106 A549 cells infected with lentivirus expressing miR-218 or miR-control were injected subcutaneously into two groups of nude mice (five mice per group). Tumor volumes were measured once per week. c and d Tissue levels of phosphorylated STAT3 and Ki67 in an A549 xenograft were visualized by immunofluorescence co-staining with DAPI