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Fig. 7 | Molecular Cancer

Fig. 7

From: Long noncoding RNA ZEB1-AS1 epigenetically regulates the expressions of ZEB1 and downstream molecules in prostate cancer

Fig. 7

Schematic representation summarizing data from the present study. ZEB1-AS1 was transcribed from the promoter region of ZEB1 in the antisense strand with respect to ZEB1. ZEB1-AS1 recruited the H3K4 methyltransferase MLL1 to ZEB1 promoter and induced H3K4me3 modification in that region. The H3K4me3 modification changed the chromatin status from an inactive state to an active state so as to facilitate ZEB1 transcription. ZEB1 participated in the regulation of malignancy behaviors such as invasion, proliferation and other functions by regulating downstream molecules such as miR200c and BMI1

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Molecular Cancer

ISSN: 1476-4598