Skip to main content
Fig. 7 | Molecular Cancer

Fig. 7

From: Hypoxic exosomes facilitate bladder tumor growth and development through transferring long non-coding RNA-UCA1

Fig. 7

Circulating exosomal lncRNA-UCA1 serves as a potential non-invasive biomarker for bladder cancer diagnosis. a Transmission electron microscopy images of serum-derived exosomes from bladder cancer (BC) patients and healthy individuals. b Western blotting analysis for exosomal markers TSG101, CD63, Hsp70 and Hsp90 of serum-derived exosomes from bladder cancer patients and healthy individuals. c RT-PCR analysis of the fragments of lncRNA-UCA1 in 5637 cells and serum-derived exosomes from bladder cancer patients and healthy individuals. d qRT-PCR analysis of lncRNA-UCA1 expression in serum-derived exosomes from bladder cancer patients and healthy individuals (mean ± S.E.M., *P < 0.05) and data were normalized with GAPDH. e The ROC curve for the serum-derived exosomal lncRNA-UCA1 and GAPDH is an internal control. f Representative immunohistochemical staining images of higher expression of HIF-1α in bladder cancer samples with high exosomal lncRNA-UCA1 levels and lower expression of HIF-1α in samples with low exosomal lncRNA-UCA1 levels (scale bar: 100 μm). g Correlation analysis between immunohistochemistry (IHC) scores of HIF-1α and the expression levels of exosomal lncRNA-UCA1 in the serum of bladder cancer patients

Back to article page