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Table 1 TMEM16A expression and function in cancers

From: Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer

Author/year Cancer type Cancer cells Human samples
Cell lines Overexpression mechanism Signaling pathways Proliferation Migration Expression Clinical outcome of overexpression
Britschgi et al./2013 [42] Breast cancer ZR75–1, HCC1954, MDA-MB-415 11q13 amplification EGFR
CAMKII
+ NR High expression due to gene amplification Poor survival
Wu et al./2015 [43] Breast cancer NR NR NR NR NR High expression Good prognosis in PR+ or HER2 breast cancer patients following tamoxifen treatment
Wu et al./2017 [95] Breast cancer MCF-7,
MDA-MB-435S
NR NR + (MCF-7)
- (MDA-MB-435S)
NR High expression Good prognosis in PR+ or HER2 breast cancer patients the low expression of Ki67
Ubby et al./2013 [94] Breast cancer HEK293 cells transfected with TMEM16A NR NR No effect No effect mRNA isoforms similar to normal tissue NR
Duvvuri et al./2012 [44] HNSCC UM-SCC1 11q13 amplification Ras-Raf-Mek-ERK1/2 + NR High expression Poor survival
Ruiz et al./2012 [45] HNSCC BHY 11q13 amplification NR No effect + High expression due to gene amplification Poor survival
Ayoub et al./2010 [46] HNSCC HEp-2
SCC-25
NR NR No effect + High expression due to gene amplification Distal metastasis
Shiwarski et al./2014 [74] HNSCC UM-SCC1 Low expression of TMEM16A via promoter hypermethylation NR NR High expression in primary tumor and low expression in nodal metastatic tissue NR
Rodrigo et al./2015 [47] HNSCC NR NR NR NR NR High expression due to gene amplification No correlation with clinical parameter; affects patient’s survival depending on tumor’s site.
Dixit et al./2015 [73] HNSCC HPV-negative FaDu
PE/CE-PJ34
NR NR + NR High expression in HPV-negative HNSCC via promoter hypomethylation Decreased survival in HPV-negative HNSCC
Bill et al./2015 [79] HNSCC Te11 11q13 amplification EGFR signaling + NR NR NR
Wanitchakool et al./2017 [59] HNSCC
Colon cancer
BHY, CAL33
HT29, T84
11q13 amplification
Epigenetic regulation by HDAC
NR + (BHY, CAL33)
- (HT29)
+ NR NR
Shi et al./2013 [50] ESCC KYSE30
KYSE510
11q13 amplification NR + NR High expression due to gene amplification Lymph node metastasis and advance clinical stage
Cha et al./ 2015 [71] Prostate cancer PC3
LnCap
Transcriptional regulation by testosterone AKT activation + NR High expression NR
Matsuba et al./2014 [77] Prostate cancer
Breast cancer
PC-3
LNCaP
YMB1
Epigenetic regulation by HDAC NR + NR NR NR
Mokutani et al./2016 [49] Colorectal cancer DLD-1
HCT116
miR-132 downregulation NR NR NR High expression due to low expression of miR-132 Poor survival
Sui et al./ 2014 [48] Colorectal cancer SW620, HCT116 LS174T Gene amplification MAPK (MEK and ERK1/2) signaling + + NR NR
Cao et al./2017 [55] Gastric cancer AGS
BGC823
MiR-381 downregulation TGFβ signaling NR + High expression due to miR-381 downregulation Metastasis and poor prognosis
Deng et al./2016 [52] Hepatocellular carcinoma SMMC-7721 NR MAPK (p38 and ERK1/2) signaling + + High expression NR
Liu et al./2014 [56] Glioma U87MG
U251
SHG44
U118
NR NFκB + + High expression NR
Jia et al./2015 [51] Lung cancer GLC82
NCI-H520
NR NR + + High expression NR
Sauter et al./ 2015 [92] Pancreatic ductal adenocarcinoma BxPC-3,
AsPC-1,
Capan-1
NR NR No effect + NR NR
Simon et al./2013 [93] GIST GIST-T1
GIST-882
NR NR No effect NR NR NR
Liu et al./2015 [54] Gastric cancer AGS
BGC-823
NR TGF-β signaling No effect + High expression Poor prognosis
  1. NR not reported, + increased, −, inhibited