Fig. 1
From: Tumor-related interleukins: old validated targets for new anti-cancer drug development
Interactions between tumor cells and infiltrating immune cells in the tumor microenvironment
Cytokines secreted by both tumor and immune cells could either induce tumor suppression or promote tumor progression. Acute inflammatory response through IL-2, IL-15, and IL-21 activates antimpetumor immune response by activating NK and CTL cells. However, chronic inflammation results in tumor cells escape from immune response through the action of different mediators especially, IL-1, IL-4 and IL-6.