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Fig. 3 | Molecular Cancer

Fig. 3

From: Overexpression of lncRNA IGFBP4–1 reprograms energy metabolism to promote lung cancer progression

Fig. 3

Upregulation of endogenous lnc-IGFBP4–1 promotes lung cancer cell proliferation in vitro. PC9 cells were transfected with lnc-IGFBP4–1-upregulation vector (pLnc-IGFBP4–1) (or empty vector as control), respectively. a CCK8 assay and b clone formation were performed to determined the cell proliferation. The results from three independent experiments, showed as mean ± s.d. c Cell-cycle analysis was conducted by flow cytometric analysis and showed cell division at the G0 – G1 stage. d Apoptosis was detected by flow cytometry. UL, necrotic cells; UR, terminal apoptotic cells; LR, early apoptotic cells. e and f Migration and invasion capacities determined by Transwell assays. *P < 0.05, **P < 0.01

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