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Fig. 5 | Molecular Cancer

Fig. 5

From: miR-92b-3p acts as a tumor suppressor by targeting Gabra3 in pancreatic cancer

Fig. 5

Gabra3 knockdown inhibited cell growth, migration and invasion in PC. a-b AsPC-1 and SW1990 cell lines were transfected with GABRA3 shRNAs or a negative control, and cell proliferation was measured by MTS assays. c-e Colony formation assays of PC cells transfected with GABRA3 shRNAs or negative control. f-h Wound healing assays were used to assess the motility of cells transfected with Gabra3 shRNAs or negative control. i-k Transwell assays were used to assess the invasion ability of PC cells transfected with Gabra3 shRNAs or negative control. l-m Flow cytometric analyses of Annexin V-FITC staining were used to quantify apoptosis in PC cells transfected with Gabra3 shRNAs or negative control. All n = 3; bar, SEM; Compared with negative control group, n.s., no significant difference, *P < 0.05, **P < 0.01, ***P < 0.001, Student’s t test

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