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Fig. 4 | Molecular Cancer

Fig. 4

From: A novel mechanism of lncRNA and miRNA interaction: CCAT2 regulates miR-145 expression by suppressing its maturation process in colon cancer cells

Fig. 4

CCAT2 inhibits maturation process of miR-145. The pri-miR-145 containing pre-miR-145 and up and down-stream flanking sequence was synthesized, subsequently incubated with nuclear or cytosolic fraction in the presence or absence of CCAT2. (a) qRT-PCR showing the relative concentration of mature miR-145 following incubation with nuclear or cytoplasmic fractions. (b) The levels of pri-, pre- and mature miR-145 in the control or after digestion with recombinant human Dicer. All the data represent means ± SEM, *P < 0.001, compared to the control

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