Fig. 1

The specific upregulation of SNAI2 in the ovarian tumor stroma. a Boxplots showing the expression level of SNAI2 in microdissected normal epithelium, normal stroma, tumor epithelium and tumor stroma included in the ovarian dataset GSE40595. b Oncomine analysis of SNAI2 in the microdissected normal and tumor stroma in the breast profile GSE9014. c Boxplots showing the expression level of SNAI2 in the microdissected normal and tumor epithelium of GSE38666. d Boxplots showing the expression level of SNAI2 in the normal epithelium, the DCIS epithelium and the invasive epithelium of GSE14548. e–h Boxplots showing the expression level of SNAI2 in the tumor and stroma compartment in the ovarian dataset GSE38666 (e). and GSE9890 (f)., the breast dataset GSE14548 (g). and the colon dataset GSE35602 (h). i Illustration of the relative gene expression of SNAI2 in the epithelial cells, leukocytes, endothelial cells, and fibroblasts as deposited in the colon cancer profile GSE39396. j Immunoblot showing the expression of SNAI1, SNAI2 and aSMA in the microdissected normal ovarian fibroblasts and the cancer associated fibroblasts from OC patients. MRC5-CAFs served as the positive control for activated fibroblasts. GAPDH served as the loading control. k–l Immunofluorescence staining showing the relative expression of SNAI1 (k). and SNAI2 (l). in the normal ovarian fibroblasts and in the cancer associated fibroblasts from OC patients. The nuclei were counterstained with DAPI. The P value is indicated