Skip to main content
Fig. 2 | Molecular Cancer

Fig. 2

From: Reprogramming of stromal fibroblasts by SNAI2 contributes to tumor desmoplasia and ovarian cancer progression

Fig. 2

SNAI2 expression is associated with a reactive and desmoplastic stroma in OC. a Scatter plots and Spearman’s correlation showing the expression level of SNAI2 and that of the calculated stroma score in the Tothill’s dataset GSE9891. b Boxplots showing the relative SNAI2 expression in the major molecular subtypes (C1-C4) of GSE9891. c Scatter plots and Spearman’s correlation showing the expression level of SNAI2 and that of the calculated stroma score in the ovarian TCGA dataset. d Boxplots showing the relative SNAI2 expression in various subtypes of the ovarian TCGA dataset. e and f GSEA plot of the association between gene sets positively correlated with SNAI2 in the stroma profile of GSE40595 and the signatures representative of myofibroblast activation (e) or the signatures predictive of patient prognosis in the tumor stroma (f). g and h Scoring of SNAI2 in the stromal compartment of OC tissues with variant tumor stroma matrix (Loose stroma, moderate stroma and dense stroma) stratified by the aSMA staining (g) and Masson’s staining (h). The P value is indicated

Back to article page