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Fig. 1 | Molecular Cancer

Fig. 1

From: Profiling, clinicopathological correlation and functional validation of specific long non-coding RNAs for hepatocellular carcinoma

Fig. 1

Expression differences and enrichment analysis of mRNAs in HCC tumor vs. paired adjacent normal tissues. a Hierarchical clustering analysis of 439 differentially expressed genes (DEGs) between 12 HCC tumor and paired adjacent normal tissue samples (log2-fold change >2 or <−2 and P < 0.05). Columns represent each gene, and rows represent each patient. The relative expression levels of mRNAs are depicted into color scale ranging from green (down-regulation) to red (up-regulation). b Real-time PCR validation of 25 DEGs in 21 HCC tumor and paired adjacent normal tissue samples, and 22 DEGs of statistical significance are presented in a box diagram (P < 0.05) with median bar indicated inside. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is used as a reference gene. c Pie charts of the top ten KEGG pathways of 439 DEGs enriched by DAVID. d Pie charts of top ten GO terms for biological process. e Pie charts of the top ten terms for genetic associated diseases

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