| lncRNAs | Function | Mechanisms | References |
---|---|---|---|---|
Up-regulated | ANRIL | Promotes cell proliferation | Interacts with PRC2 to silent KLF2 | [43] |
MALAT1 | Induces apoptosis, activates mTOR pathway | Increases the splicing factor SRSF1 | [45] | |
PCNA-AS1 | Promotes tumour growth | Forms a duplex with PCNA, increases PCNA stability | [46] | |
CCAT1 | Promotes cell proliferation and migration | Binds let-7 as a ceRNA | [48] | |
Unigene56159 | Induces EMT and migration | Binds miR-140-5p as a ceRNA | [49] | |
TP73-AS1 | Promotes cell proliferation | Competes with HMGB1 to bind miR200a, activate HMGB1/RAGE axis | [52] | |
CCAT2 | Promote cell proliferation, EMT and reduces apoptosis | Up-regulates Snail2 | ||
uc.338 | Promotes cell proliferation | Interacts with BMI1 | [54] | |
UCA1 | Promotes invasion and EMT | Interacts with miR-203, regulates the expression of Snail2 | [58] | |
SPRY4-IT1 | Promotes EMT | Up-regulates twist1 and Vimentin, reduces the expression of E-cadherin | [60] | |
SNHG20 | Promotes EMT | Up-regulates twist1 and Vimentin, reduces the expression of E-cadherin | ||
TUG1 | Induces drug resistance | Regulates the expression of P-gp and MDR1 | [65] | |
HULC | Induces resistance to oxaliplatin, 5-FU and THP | Activates autophagy | [67] | |
HOTAIR | Damages DNA repair and induces MSI | Reduces the recruitment of P300, RNA Pol II and CREB to SETD2 promoter | [73] | |
lncBRM | Maintains stemness and properities of LCSCs | Interacts with BRM and activates YAP1 signalling | [29] | |
CUDR | Promotes growth of LCSCs | Up-regulates CyclinD1, down-regulated PTEN | [74] | |
lncTCF7 | Promotes self-renewal and propagation of CSCs | Recruits SWI/SNF complex, activates Wnt pathway | [30] | |
lnc-β-catenin | Regulates self-renewal of LCSCs | Mediates the formation of β-catenin -EZH2 complex, activates Wnt signalling | [31] | |
lncRNA CAMTA1 | Maintains CSC properties | Regulates the expression of CAMTA1 | [32] | |
lncRNA DANCR | Maintains stemness of LCSCs | Impairs interaction between CTNNB1 and miRNA as a ceRNA | [77] | |
PVT1 | Promotes cell proliferation and stem cell-like features | Stabilizes NOP2 | [89] | |
Down-regulated | H19 | Mediates metastasis of HCC | Binds hnRNP U/PCAF/RNA Pol II complex to increase the expression of miR-200 family | [44] |
BANCR | Promotes cell proliferation | Â | [55] | |
lnc-FTX | Modulate cell proliferation | Interacts with MCM2 and binds miR-374a as a ceRNA | [56] | |
lnc-DILC | Promotes expansion of LCSCs | Inhibits IL-6/JAK2/STAT3 | [28] |