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Fig. 4 | Molecular Cancer

Fig. 4

From: Hdac7 promotes lung tumorigenesis by inhibiting Stat3 activation

Fig. 4

HDAC7 regulates STAT3 phosphorylation. a. Representative Western blot (left panel) and statistics analyses of the phosphorylation of Stat3 proteins in individual lung tumors isolated from Hdac7 +/−/K-Ras and control mice. b, Representative Western blot (left panel) and quantitative (right panel) analyses of Stat3 phosphorylation level in H1299 cells expressing shHDAC7 and scramble shRNA. c, HDAC7 overexpression significantly abrogates STAT3 phosphorylation. Representative Western blot analyses of STAT3 phosphorylation level in H1299 cells transfected with pMX-Hdac7 and pMX control plasmids. The values in statistics analyses in (a and b) represent the means ± SD. of three separate experiments. ***, p<0.001

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