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Fig. 3 | Molecular Cancer

Fig. 3

From: Knockdown of SOX2OT inhibits the malignant biological behaviors of glioblastoma stem cells via up-regulating the expression of miR-194-5p and miR-122

Fig. 3

MiR-194-5p and miR-122 mediated the tumor-suppressive effects of SOX2OT knockdown on GSCs. a CCK-8 assay was used to measure the effect of SOX2OT and miR-194-5p on the proliferation of GSC-U87 and GSC-U251 cells. b Flow cytometry analysis to evaluate the effect of SOX2OT and miR-194-5p on the apoptosis of GSC-U87 and GSC-U251 cells. c Transwell assays was used to measure the effect of SOX2OT and miR-194-5p on the migration and invasion of GSC-U87 and GSC-U251 cells. Data are presented as the mean ± SD (n = 5, each group).** P < 0.01 vs. sh-NC + agomir-194-5p-NC. d CCK-8 assay was used to measure the effect of SOX2OT and miR-122 on the proliferation of GSC-U87 and GSC-U251 cells. e Flow cytometry analysis to evaluate the effect of SOX2OT and miR-122 on the apoptosis of GSC-U87 and GSC-U251 cells. f Transwell assays was used to measure the effect of SOX2OT and miR-122 on the migration and invasion of GSC-U87 and GSC-U251 cells. Scale bars represent 40 μm. Data are presented as the mean ± SD (n = 5,each group) . ** P < 0.01 vs. sh-NC + agomir-122-NC

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Molecular Cancer

ISSN: 1476-4598