Fig. 6

SOX3 mediated tumor-suppressive effects of miR-194-5p and miR-122. a CCK8 assay to evaluate the effect of miR-194-5p and SOX3 on cell proliferation of GSC-U87 and GSC-U251 cells. b Flow cytometry analysis to evaluate the effect of miR-194-5p and SOX3 on cell apoptosis of GSC-U87 and GSC-U251 cells. c Transwell assay to evaluate the effect of miR-194-5p and SOX3 on the cell migration and invasion of GSC-U87 and GSC-U251 cells. Data are presented as the mean ± SD (n = 5, each group). Scale bars represent 40 μm. ^** P < 0.01 vs. AgomiR-194-5p-NC + SOX3(+)NC group, ^## P < 0.01 vs. AgomiR-194-5p + SOX3(+)NC group. d CCK8 assay to evaluate the effect of miR-122 and SOX3 on cell proliferation of GSC-U87 and GSC-U251 cells. e Flow cytometry analysis to evaluate the effect of miR-122 and SOX3 on cell apoptosis of GSC-U87 and GSC-U251 cells. f Transwell assay to evaluate the effect of miR-122 and SOX3 on the cell migration and invasion of GSC-U87 and GSC-U251 cells. Data are presented as the mean ± SD (n = 5, each group). Scale bars represent 40 μm. ^** P < 0.01 vs. AgomiR-122-NC + SOX3(+)NC group, ^## P < 0.01 vs. AgomiR-122 + SOX3(+)NC group