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Fig. 2 | Molecular Cancer

Fig. 2

From: Long noncoding RNA NORAD, a novel competing endogenous RNA, enhances the hypoxia-induced epithelial-mesenchymal transition to promote metastasis in pancreatic cancer

Fig. 2

NORAD promotes cell migration and invasion in vitro and in vivo. a The migration and invasion abilities of tumor cells were assessed using wound healing assays as well as transwell migration and invasion assays. Left panel: wound healing assays (photographed after 24 h), middle panel: transwell migration assays (photographed after 12 h), right panel: transwell invasion assays (photographed after 12 h); b The distances between wound edges after 0 h and 24 h; c-d Histograms showing the numbers of cells that have migrated or invaded after 0 h and 12 h; e SW1990-sh-NORAD and SW1990-sh-NC were labeled with firefly luciferase and injected into the abdominal cavity of nude mice (n = 5). The bioluminescent signal was assessed 3 weeks after injection; f Histogram showing the bioluminescent signal intensity detected using a noninvasive In Vivo Imaging System; g Representative H & E staining images of liver and gastric wall from the different groups. Yellow star: micrometastatic folic, red triangle: gastric mucosa. *p < 0.05 **p < 0.01, ***p < 0.001

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