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Fig. 7 | Molecular Cancer

Fig. 7

From: Long noncoding RNA MALAT1 regulates autophagy associated chemoresistance via miR-23b-3p sequestration in gastric cancer

Fig. 7

MALAT1 regulates autophagy via ATG12. a Western blot analysis to confirm the efficacy of overexpression of ATG12. SGC7901/VCR cells were transfected with pcDNA3.1- empty vector, shRNA-MALAT1, shRNA-MALAT1+ pcDNA3.1-ATG12. LC3-II expression was evaluated by Western blot. b The decreased IC50 values induced by MALAT1 knockdown could be relieved by ATG12 or miR-23b-3p inhibitors. c SGC7901/VCR cells were transfected with inhibitor NC, shRNA-MALAT1, shRNA-MALAT1+ miR-23b-3p inhibitor. LC3-II expression was evaluated by Western blot. d SGC7901/VCR cells were transfected with inhibitor NC, LV-MALAT1, LV-MALAT1+ miR-23b-3p mimics. LC3-II expression was evaluated by Western blot. Data shown are means ± S.D. (n = 3; two-tailed t-test). *, p < 0.05

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Molecular Cancer

ISSN: 1476-4598