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Fig. 3 | Molecular Cancer

Fig. 3

From: microRNA-124 inhibits bone metastasis of breast cancer by repressing Interleukin-11

Fig. 3

The effect of miR-124 on bone metastasis from breast cancer cells in mice. a Images of luciferase signal in nude mice inoculated with luciferase-labeled MDA-MB-231 cells stably expressing miR-124 or NC into the left ventricle (Left). Representative X-ray imagings of tibias from mice are shown on the right. The arrow indicates osteolytic lesion. b Statistical analysis showed reduced luciferase signal in nude mice inoculated with luciferase-labeled MDA-MB-231 cells stably expressing miR-124. Horizontal line indicates median value. P = 0.0006 by Mann–Whitney U test. c Images of luciferase signal in nude mice inoculated with luciferase-labeled MCF7 cells stably expressing miR-124 inhibitor (in-miR-124) or NC (in-NC) into the left ventricle. d Statistical analysis showed a significant increase of luciferase signal in nude mice inoculated with luciferase-labeled MCF7 cells stably expressing miR-124 inhibitor. Horizontal line indicates median value. P = 0.0159 by Mann–Whitney U test. e Images of luciferase signal in nude mice inoculated with MDA-MB-231 cells and then injected with ago-miR-124 or NC (Left). Representative X-ray imagings of tibias from mice are shown on the right. The arrow indicates osteolytic lesion. f Statistical analysis showed significantly lower luciferase signal in nude mice inoculated with luciferase-labeled MDA-MB-231 cells and then injected with ago-miR-124 than in mice injected with NC. Horizontal line indicates median value. P = 0.0022 by Mann–Whitney U test

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