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Fig. 7 | Molecular Cancer

Fig. 7

From: microRNA-124 inhibits bone metastasis of breast cancer by repressing Interleukin-11

Fig. 7

The miR-124/IL-11 axis is perturbed in breast cancer patients with bone metastasis. a Kaplan-Meier analysis for bone metastasis-free survival of 79 patients who received breast cancer surgery and a follow-up of the development of bone metastasis. The median value of miR-124 expression in primary breast cancer tissues as detected by ISH from all 79 samples was chosen as the cut-off point. P = 0.033 by log rank test. b A correlation analysis was performed between miR-124 expression of bone metastasis tissues from 34 patients that received bone metastasis resection and the time from primary breast cancer surgery to bone metastasis development. r = 0.45, p = 0.0065 by Spearman correlation analysis. c-e Percentages of specimens with low or high miR-124 expression were relative to percentages of specimens with KPS ≥ 80 or KPS < 80 (c), and specimens with single bone lesion or multiple bone lesions (d) as well as specimens with Ki67 < 14% or Ki67 ≥ 14% (e). * P < 0.05 by Fisher’s exact test. f Kaplan-Meier analysis for the overall survival of 34 patients with bone metastasis. The median value of all 34 samples was chosen as the cut-off point. P = 0.035 by log rank test. g Percentages of specimens with low or high miR-124 expression relative to the levels of IL-11 protein. ** P < 0.01 by Fisher’s exact test. h Kaplan-Meier analysis was used to compare the overall survival of patients with higher expression of IL-11 and lower expression of IL-11. The median value of IL-11 in all 34 samples was chosen as the cut-off point. P = 0.007 by log rank test. i A schematic representation of the miR-124/IL-11 regulatory axis in the interaction between primary breast cancer and bone microenvironment

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