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Fig. 7 | Molecular Cancer

Fig. 7

From: HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

Fig. 7

HSP90 enhanced the glycolysis and proliferation while decreased the apoptosis of HCC cells through PKM2. Huh7 cells were co-transfected with corresponding vectors. Overexpression of HSP90 significantly increased (a) glucose consumption, (b) lactate production and (c) PK activity of Huh7 cells. PKM2 knockdown abrogated the promoting effects of HSP90 on glycolysis. Furthermore, overexpression of HSP90 significantly (d) increased proliferation while decreased the (e) Caspase-3 activity and (f) apoptosis of Huh7 cells. PKM2 knockdown abrogated the regulatory effects of HSP90 overexpression on cell proliferation and apoptosis. *, P < 0.05 by t test

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