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Fig. 8 | Molecular Cancer

Fig. 8

From: HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

Fig. 8

HSP90 promoted the growth of Huh7 cells through PKM2 in vivo. a Subcutaneous injection was performed using Huh7 cells co-transfected with corresponding vectors. Overexpression of HSP90 significantly increased the growth of Huh7 cells in nude mice while PKM2 knockdown abrogated the promoting effects of HSP90 on the growth of Huh7 cells in vivo. *, P < 0.05 by two-way ANOVA. b Tumor nodules were subjected to IHC staining for Ki-67, TUNEL assays and quantitative analysis. IHC staining for Ki67 and TUNEL assays revealed that HSP90 overexpression significantly increased the number of Ki-67 positive cells and decreased the number of apoptotic cells. These effects induced by HSP90 overexpression were abrogated by PKM2 knockdown. *, P < 0.05 by One-way ANOVA

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Molecular Cancer

ISSN: 1476-4598