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Table 1 Clinical correlation of HSP90 and PKM2 expression in HCC

From: HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

Clinicopathological
Features
n HSP90 P value PKM2 P value
Positive Negative Positive Negative
Age (y) <50 32 20 12 0.086 18 14 0.669
≥50 68 29 39 34 34
Sex Male 65 31 34 0.834 35 30 0.677
Female 35 18 17 17 18
HBV Absent 31 17 14 0.518 18 13 0.517
Present 69 32 37 34 35
Cirrhosis Absent 21 12 9 0.466 9 12 0.462
Present 79 37 42 43 36
AFP level (ng/mL) <400 22 13 9 0.338 6 16 0.015
≥400 78 36 42 46 32
Tumor size
(cm)
<5 55 18 37 0.006 21 34 0.003
≥5 45 31 14 31 14
PVTT Absent 36 10 26 0.002 11 25 0.002
Present 64 39 25 41 23
TNM stage I + II 59 20 39 0.005 24 35 0.008
III + IV 41 29 12 28 13
  1. Significant values (P<0.05) are in italic and bold