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Table 1 Clinical correlation of HSP90 and PKM2 expression in HCC

From: HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

Clinicopathological

Features

n

HSP90

P value

PKM2

P value

Positive

Negative

Positive

Negative

Age (y)

<50

32

20

12

0.086

18

14

0.669

≥50

68

29

39

34

34

Sex

Male

65

31

34

0.834

35

30

0.677

Female

35

18

17

17

18

HBV

Absent

31

17

14

0.518

18

13

0.517

Present

69

32

37

34

35

Cirrhosis

Absent

21

12

9

0.466

9

12

0.462

Present

79

37

42

43

36

AFP level (ng/mL)

<400

22

13

9

0.338

6

16

0.015

≥400

78

36

42

46

32

Tumor size

(cm)

<5

55

18

37

0.006

21

34

0.003

≥5

45

31

14

31

14

PVTT

Absent

36

10

26

0.002

11

25

0.002

Present

64

39

25

41

23

TNM stage

I + II

59

20

39

0.005

24

35

0.008

III + IV

41

29

12

28

13

  1. Significant values (P<0.05) are in italic and bold