Fig. 6

Fhit changes the ribosome occupancy ratio of 5’-UTR versus coding region. Ribosome distribution is shown across the mRNAs identified in Table 2 as having changes to 5’-UTR/coding region ribosome occupancy in Fhit-positive (blue) vs Fhit-negative (red) cells. Omitted are mRNAs from Table 2 whose ribosome distribution is presented in Fig. 4. The 5’-UTR of each mRNA is shaded. a Five mRNAs showed increased ribosome loading in both the 5’-UTR and the coding region, but the increases observed in the 5’-UTR were larger than those observed in the coding region. b Four mRNAs exhibited an increase in 5’-UTR-bound ribosomes while their coding regions remained essentially unchanged. c Two mRNAs showed decrease 5’-UTR ribosome occupancy in Fhit-positive versus Fhit-negative cells, but increased coding region ribosome occupancy. d Two mRNAs showed decreased 5’-UTR ribosome occupancy in Fhit-positive versus Fhit-negative cells but little change in coding region ribosome occupancy