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Fig. 5 | Molecular Cancer

Fig. 5

From: MiR-25-3p promotes the proliferation of triple negative breast cancer by targeting BTG2

Fig. 5

BTG2 is a direct target of miR-25-3p. a. BTG2 expression is suppressed in triple negative breast cancer samples when compared to luminal breast samples. b. Negative correlation between the expression levels of miR-25 and BTG2 in breast cancer specimens from TCGA database (r = −0.243, P < 0.05). c. The seed sequence of miR-25-3p is complementary to the 3’UTR of BTG2. d. Luciferase activity was analyzed in cells co-transfected with miR-25-3p mimics or negative control with GV272-BTG2 or GV272-BTG2-mut1/2. e. Western blot analysis showing suppression of BTG2 protein levels in TNBC cells transfected with miR-25-3p mimics. f. Expression of BTG2 mRNA in TNBC cells after miR-25-3p expression alteration by qRT-PCR. *p < 0.05, **p < 0.01. The data expressed as the mean ± SD

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