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Fig. 6 | Molecular Cancer

Fig. 6

From: STAT3-induced lncRNA HAGLROS overexpression contributes to the malignant progression of gastric cancer cells via mTOR signal-mediated inhibition of autophagy

Fig. 6

HAGLROS antagonized miR-100-5p-mediated mTOR mRNA degradation. a The relative expression levels of autophagy-related signals mTOR and ATG9A/9B were validated by qRT-PCR upon HAGLROS knockdown in accordance with RNA high-throughput sequencing guidelines. b Bioinformatic analysis of the interactions of HAGLROS with miR-100-5p and mTOR mRNA. c The effect of miR-100-5p overexpression by transfection with miR-100-5p mimics on mTOR mRNA level in GC cells. d Relative luciferase activity of mTOR mRNA 3’-UTR was determined after transfection with miR-100-5p mimics, miR-100-5p inhibitor or HAGLROS plasmid. Error bars indicate the means ± S.E.M. *P < 0.05, **P < 0.01

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Molecular Cancer

ISSN: 1476-4598