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Fig. 7 | Molecular Cancer

Fig. 7

From: STAT3-induced lncRNA HAGLROS overexpression contributes to the malignant progression of gastric cancer cells via mTOR signal-mediated inhibition of autophagy

Fig. 7

Bioinformatics prediction and experimental verification of HAGLROS binding to mTORC1 components. a Bioinformatic analysis of HAGLROS interacting with mTORC1 components. Values greater than 0.5 for both the RF classifier and the SVM classifier indicate a high possibility of interaction. b HAGLROS levels in immunoprecipitates are presented as fold enrichment in mTOR, Raptor and PRAS40 antibodies relative to IgG immunoprecipitates by RIP experiments. c Coomassie brilliant blue staining of mTOR, Raptor and PRAS40 protein levels by SDS-PAGE of immunoprecipitates from HAGLROS pulldown. d Western blot analysis of mTOR, Raptor and PRAS40 protein levels in immunoprecipitates from HAGLROS pulldown. **P < 0.01

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Molecular Cancer

ISSN: 1476-4598