Fig. 8From: Paracrine and epigenetic control of CAF-induced metastasis: the role of HOTAIR stimulated by TGF-ß1 secretionThe proposed model of the paracrine and epigenetic mechanism of CAFs induced EMT and metastasis in breast cancer. CAFs secreted high levels of TGF-β1, resulting in the transactivation of HOTAIR in breast cancer cells, consequently enhanced metastasisBack to article page