Table 1 Univariate analysis and Cox regression multivariate analysis of PAI-2 in cancer cells in clinical CCA samples and patient clinicopathological parameters
Parameters (no. of cases) | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
PAI-2 in cancer cells | P-value | OR (95% CI) | P-value | |||
High | Low | |||||
High PAI-2 expression (72) |  | 45 | 27 | – | 3.452 (1.188-10.030) | 0.023 |
Age (y) (72) | < 60 | 24 | 13 | 0.808 | 1.00 (0.499-2.003) | 1.000 |
≥ 60 | 21 | 14 | ||||
Gender (72) | Male | 25 | 17 | 0.625 | 1.291 (0.683-2.443) | 0.432 |
Female | 20 | 10 | ||||
Tumor size (cm) (67) | < 5 | 15 | 9 | 0.790 | 1.375 (0.698-2.705) | 0.357 |
≥ 5 | 29 | 14 | ||||
Tumor staging (72) | I - III | 8 | 10 | 0.093 | 0.963 (0.359-2.579) | 0.940 |
IV | 37 | 17 | ||||
Histological type (72) | WD | 23 | 9 | 0.220 | – | 0.008 |
MD | 6 | 4 | 1.000 | 2.034 (0.915-4.519) | 0.081 | |
PD | 2 | 5 | 0.095 | 4.414 (1.1610-12.106) | 0.004 | |
Pap | 14 | 9 | 1.000 | 6.199 (1.754-21.909) | 0.005 | |
Vascular invasion (51) | Absence | 18 | 16 | 0.065 | 0.405 (0.190-0.866) | 0.020 |
Presence | 14 | 3 | ||||
LN metastasis (72) | Absence | 28 | 20 | 0.439 | 2.078 (0.925-4.670) | 0.077 |
Presence | 17 | 7 | ||||