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Table 1 Univariate analysis and Cox regression multivariate analysis of PAI-2 in cancer cells in clinical CCA samples and patient clinicopathological parameters

From: The microRNA-15a-PAI-2 axis in cholangiocarcinoma-associated fibroblasts promotes migration of cancer cells

Parameters (no. of cases) Univariate Multivariate
PAI-2 in cancer cells P-value OR (95% CI) P-value
High Low
High PAI-2 expression (72)   45 27 3.452 (1.188-10.030) 0.023
Age (y) (72) < 60 24 13 0.808 1.00 (0.499-2.003) 1.000
≥ 60 21 14
Gender (72) Male 25 17 0.625 1.291 (0.683-2.443) 0.432
Female 20 10
Tumor size (cm) (67) < 5 15 9 0.790 1.375 (0.698-2.705) 0.357
≥ 5 29 14
Tumor staging (72) I - III 8 10 0.093 0.963 (0.359-2.579) 0.940
IV 37 17
Histological type (72) WD 23 9 0.220 0.008
MD 6 4 1.000 2.034 (0.915-4.519) 0.081
PD 2 5 0.095 4.414 (1.1610-12.106) 0.004
Pap 14 9 1.000 6.199 (1.754-21.909) 0.005
Vascular invasion (51) Absence 18 16 0.065 0.405 (0.190-0.866) 0.020
Presence 14 3
LN metastasis (72) Absence 28 20 0.439 2.078 (0.925-4.670) 0.077
Presence 17 7
  1. WD well differentiated, MD moderately differentiated, PD poorly differentiated, Pap papillary, OR odd ratio, 95% CI 95% confidence interval, LN lymph node