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Fig. 1 | Molecular Cancer

Fig. 1

From: Long non-coding RNA implicated in the invasion and metastasis of head and neck cancer: possible function and mechanisms

Fig. 1

General mechanisms of HNC metastasis regulated by lncRNA based on their subcellular localization. Nulclear lncRNAs modulate metastasis-associated gene expression through chromatin modification, transcriptional control and mRNA/miRNA processing. For instance, mRNA processing includes alternative splicing of mRNA; besides, some lncRNAs could be spliced into pri-miRNAs, thus producing miRNAs. In the cytoplasm, lncRNAs serve as players in mRNA stability modulation, protein stability control, translational control and miRNA sponging. These lncRNAs with various functions in the HNC cell are highlighted in red as examples, while it is temporarily lacking in representatives for lncRNAs participating in HNC metastasis via mRNA/miRNA processing. LncRNA: long noncoding RNA; HNC: head and neck cancer; miRNA: microRNA

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Molecular Cancer

ISSN: 1476-4598